This publication examines the growing threat of transnational organized crime in the Americas and the Caribbean, highlighting its severe impacts on citizen security, democratic institutions, and sustainable development—particularly for marginalized communities. It underscores the evolving nature of criminal organizations, their cross-border operations, and their reliance on violence and corruption. Designed as a tool for parliamentarians, the document outlines key challenges, emerging trends, and potential national and regional responses to support inclusive and effective parliamentary action against organized crime.